What is a Eugeroic Drug?
Eugeroic drugs are a new kind of stimulant also commonly known as “smart drugs” or “nootropics”. The original smart drug, Adrafinil, was first synthesized in the 1980’s by Lafon Laboratories for the treatment of narcolepsy (day sleeping) and cataplexy (muscle weakness) However, it is an updated version of this drug, Modafinil, which is currently prescribed.
Adrafinil is actually converted to Modafinil in the liver. However, once Modafinil was synthesized, there was no longer a need for Adrafinil. Adrafinil has been picked up by other labs for manufacturing, and is now available without a prescription. Unfortunately, higher doses of Adrafinil are needed to create the same effects, and the result is the release of excessive liver enzymes.
Essentially, the effects of smart drugs include alertness and wakefulness. However, the side effects are more subtle than that of most stimulants, such as Adderall. The highs and lows of amphetamines are typically avoided.
Are Eugeroic Drugs Addictive?
The currently thinking is that smart drugs are not physically addictive. Like any drug, however, they may become habitual, and also have the propensity to develop tolerance. Unlike other stimulants, smart drugs do not appear to interfere with sleep patterns.
Since the 1980’s, several animal studies have been performed which appear to solidify Modafinil as an effective drug, and one which does not invoke severe side effects or dependency.
How Eugeroic Drugs Work
Modafinil enhances alertness by activating norepinephrine (NE). This neurotransmitter regulates alertness and the waking-sleep cycle. It is also serves to maintain attention, learning, and memory. Other central nervous system stimulants, such as amphetamines, have a number of undesirable side effects, including heart problems, mental disturbances, and addiction.
What are the Side Effects of Eugeroic Drugs? Are They Safe?
The two most common side effects of therapeutic dosages are nausea and headache. In a few cases, mild tachycardia (increased heart rate) have been reported. It is believe that those with heart conditions may be prone to this type of effect.
Also, persons with liver disease/damage should avoid taking smart drugs, as with many drugs, they can contribute to liver problems.
According to a research article published in the November, 2015 issue of European Neuropsychopharmacology:
“…modafinil appears to consistently engender enhancement of attention, executive functions, and learning. Importantly, we did not observe any preponderances for side effects or mood changes.”
What are the Therapeutic Dosages of Eugeroic Drugs?
For alertness/wakefulness, the dosage is typically 100 mg as needed throughout the day. For treatment of narcolepsy,cataplexy, and hypersomnia, 100-200 mg is typically prescribed.
Other Nootropic Drugs
Piracetam is a derivative of GABA. In the U.S., it is not approved by the FDA for medical use and it is not allowed to be sold as a dietary supplement.
Pramiracetam is an enhanced version of piracetam, and works in a similar fashion. It is considered very powerful but does not seem to influence mood, only cognitive abilities.
Phenylpiracetam is also a stronger version of Piracetam, said to be 60 times more concentrated. In addition to cognitive effects, it is said to help physical performance and exercise recover time.
Noopept works by stimulating the Nicotinic, AMPA and NDMA receptors in the brain. Thus, it increases the activity of neurotransmitters such as glutamate, acetylcholine, dopamine, and serotonin.
5-HTP is made in the body from L-Tryptophan and converts to serotonin in the brain.
Author’s Note: I used modafinil twice. The first time, I took 200 mg. I felt like my heart was racing a bit, but nothing too crazy. The second time, it didn’t really do a lot for me, but it did provide me with a headache. On the other hand, my husband at the time swore by it, although he did say he sometimes developed a headache after a few hours.
~ G. Nathalee Serrels, M.A., Psychology
If you or someone you know is an addict, please seek help immediately.